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With the human population growing at an alarming rate, the prevalence of infectious diseases has also increased. But pandemics have been around for thousands of years. The Plague of Galen, also known as the Antonine Plague was an ancient pandemic that affected Asia Minor, Egypt, Greece, and Italy in 165 AD.
How the Horrific 1918 Flu Spread Across America
https://www.smithsonianmag.com/history/journal-plague-year-180965222/